The study of Unidentified Anomalous Phenomena (UAP) presents a unique scientific opportunity that demands a rigorous, evidence-based approach. Addressing this challenge will require new and robust data acquisition methods, advanced analysis techniques, a systematic reporting framework and reducing reporting stigma. NASA – with its extensive expertise in these domains and global reputation for scientific openness – is in an excellent position to contribute to UAP studies within the broader whole-of-government framework led by the All-domain Anomaly Resolution Office (AARO).